Gemini vitamin D analog represses the expression of a stem cell marker CD 44 in breast cancer
نویسندگان
چکیده
Department of Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA (J.Y.S., H.J.L., A.K.S., S.P., C.X.W., H.M., M.U., X.Z., A.H.C., F.L., N.S.); Department of Food Science and Technology, Chung-Ang University, Anseong 456-756, South Korea (H.J.L); Department of Biomedical Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA (L.C.); Center for Advanced Biotechnology and Medicine, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA (F.L.); The Cancer Institute of New Jersey, New Brunswick, NJ 08901, USA (X.Z., A.H.C., L.C., F.L., N.S.) Molecular Pharmacology Fast Forward. Published on November 29, 2010 as doi:10.1124/mol.110.068403
منابع مشابه
A novel Gemini vitamin D analog represses the expression of a stem cell marker CD44 in breast cancer.
CD44 is a multifunctional transmembrane protein involved in cell proliferation, angiogenesis, invasion, and metastasis. CD44 is identified as a cancer stem cell marker, and the CD44-positive breast cancer cells are enriched in residual breast cancer cell populations after conventional therapies, suggesting that CD44 may be an important target for cancer prevention and therapy. Therefore, we inv...
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Introduction : Breast cancer is the most common cancer and the second cause of cancer death among women. Despite recent developments in therapeutic tools about 25% of all the involved cases die annually. The clinical, molecular, and pathologic features of breast cancer in BRCA1 mutation carriers suggest that BRCA1 may function as a stem-cell regulator. The purpose of the current study was to ...
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BACKGROUND CD44, a transmembrane glycoprotein, is a major receptor for extracellular proteins involved in invasion and metastasis of human cancers. We have previously demonstrated that the novel Gemini vitamin D analog BXL0124 [1α,25-dihydroxy-20R-21(3-hydroxy-3-deuteromethyl-4,4,4-trideuterobutyl)-23-yne-26,27-hexafluro-cholecalciferol] repressed CD44 expression in MCF10DCIS.com basal-like hum...
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